Lab: (269) 387-5503
Office: 3933 Wood Hall, Mail Stop 5410
Lab: 4017 Haenicke Hall
Department of Biological Sciences
Western Michigan University
1903 W Michigan Ave
Kalamazoo MI 49008-5410 USA
Dr. Geiser has two ongoing projects in his laboratory: identification of cellular targets of Yersinia pestis (plague) and generation of novel drugs through engineering of cyclic peptide producing organisms. Each project uses molecular biology and fungal genetics to get us to the desired goal.
Cellular targets of Yersinia pestis (plague)
Goal: To understand the structure/function relationship of protein toxins of Yersinia pestis responsible for inactivation of immune cells during infection and subsequent establishment of plague.
Dr. Geiser uses a yeast model system to identify cellular targets of YopO, YopT and YopE using the two-hybrid system and characterization of dominant suppressors. This work is pursued using genetics, molecular biology, and biochemical techniques in the yeast Saccharomyces cerevisiae.
Engineering of cyclic peptide producing organisms
Goal: To engineer fungal strains capable of expressing novel cyclic peptides with anti-biotic or anti-fungal properties.
This work is pursued using genetics, molecular biology, and biochemical techniques in multiple fungal systems.
Students in Dr. Geiser's laboratory